PCOS stands for “polycystic ovarian syndrome”. It’s not what it sounds like. It’s a metabolic and hormonal condition that happens to about 8% of all people assigned as female at birth. It can be diagnosed as early as age 9. It is a lifetime condition requiring ongoing management to take care of health risks for diabetes, heart disease and cancer. Fortunately, it is manageable!
Would it surprise you to learn that PCOS is not mainly about the ovaries? Sure, this medical condition is named after this particular part of the female anatomy. But having cysts on the ovaries is just one symptom of many, and you don’t even have to have that particular symptom to be diagnosed with PCOS. The name PCOS itself is considered by some to be misleading. Despite debate among scientists and others, the name persists.
PCOS is all about hormones! In particular, it’s about hormones that are out of balance, and have fallen into a dysfunctional cycle. Because of this cycle, a series of symptoms often go hand-in-hand. Here are some possible symptoms of PCOS, but it’s important to understand that each woman expresses PCOS in her own way. Not all symptoms apply to all people.
pcos: Latest results from PubMed
The aim of this analysis is to assess the effect of obesity on reproductive hormones in Chineses patients with polycystic ovarian syndrome (PCOS). Seven databases were searched. The Newcastle-Ottawa Scale (NOS) assessed the quality of included studies. A meta-analysis was performed using random-effects model. The means and standard deviations of the outcomes were synthesized as standardized mean differences (SMDs) with corresponding 95% confidence intervals (CIs). A total of 23 studies involving...
Published on: Sun, 27 Apr 2025 06:00:00 -0400
Authors: Xiaolin Chen, Zhuoni Xiao, Yuli Cai, Yizhuo Pan,
CONCLUSION: This study highlighted the important value of genes associated with senescence and sphingolipids dysregulation in PCOS. Aspirin targeting senescence could be a promising therapeutic drug for addressing anovulation associated with PCOS.
Published on: Sat, 26 Apr 2025 06:00:00 -0400
Authors: Weiwei Shi, Hao Lin, Wu Di, Cong He, Yang Shen,
The risk of PCOS is significantly increased in obese women, and studies have shown that weight loss can improve symptoms of PCOS. Coffee has been shown to be effective in reducing body weight. In this study, we focused on the SLC16A6 gene using bioinformatics and searched for coffee and its monomers using reverse network pharmacology. The gene expression omnibus (GEO) database was searched to screen for differentially expressed genes (DEGs) in PCOS patients. Gene ontology (GO) functional...
Published on: Sat, 26 Apr 2025 06:00:00 -0400
Authors: Tonglin Bai, Yue Hu, Jing Zhou, Ling Luo, Yuhuan Liu, Chaoqin Yu,
In five related essays, Mary Jean Walker and Wendy Rogers, joined in one essay by Jenny Doust, defend various theses about the concept of disease. First, they argue "disease" is a cluster concept, not a "classically structured" one definable by necessary and sufficient conditions. Second, "disease" is vague, in the standard philosophical sense of having borderline cases. In fascinating detail, they argue that this vagueness shows up almost everywhere one looks among ordinary diseases, even if...
Published on: Sat, 26 Apr 2025 06:00:00 -0400
Authors: Christopher Boorse,
Background: Insulin resistance, visceral adiposity, excess body weight, and symptoms of hyperandrogenism often accompanies Polycystic Ovary Syndrome (PCOS). A balanced diet plays a key role in improving the metabolic and biochemical parameters in affected women. This study aims to assess whether dietary improvements in patients with suspected PCOS may affect the severity of the disease and the metabolic and hormonal profile. Methods: The analysis of the relationships between self-declared...
Published on: Sat, 26 Apr 2025 06:00:00 -0400
Authors: Karolina Kowalczyk, Sabina Kadłubek, Aleksandra Krużel, Dominik Sikora, Jakub Daniluk, Paweł Madej,
The relationship between anti-Müllerian hormone (AMH) levels and body weight, expressed through body mass index (BMI), in women with PCOS has been a topic of discussion for a long time, yet the literature continues to present conflicting data. The latest guidelines emphasize the growing role of AMH in the diagnosis of polycystic ovary syndrome and suggest that it should become one of the diagnostic criteria for identifying this condition. Objectives: The aim of this study was to determine the...
Published on: Sat, 26 Apr 2025 06:00:00 -0400
Authors: Amalia Gorzko, Mariia Melnyk, Jolanta Nawrocka-Rutkowska, Andrzej Starczewski, Aleksandra Marciniak, Iwona Szydłowska,
Background: As a complicated endocrine condition, polycystic ovarian syndrome affects around 20% of women who are of reproductive age. It is linked to an increased risk of endometrial cancer, cardiovascular diseases, mental illnesses, non-alcoholic fatty liver disease, metabolic syndrome, and Type 2 diabetes. Despite numerous genetic studies identifying several susceptibility loci, these only account for approximately 10% of the hereditary factors contributing to PCOS, leaving its etiology...
Published on: Sat, 26 Apr 2025 06:00:00 -0400
Authors: Reema Almotairi, Rashid Mir, Kholoud S Almasoudi, Eram Husain, Nabil Mtiraoui,
Background/Objectives: Among the therapeutic options available for managing PCOS, metformin improves insulin sensitivity, reduces androgen levels, and helps restore menstrual regularity and ovulation. While primarily used for its metabolic effects, metformin therapy may also influence reproductive parameters, including AMH levels, which are pivotal in improving ovarian function and predicting therapeutic outcomes in PCOS. The aim of this study was to search the scientific literature and analyze...
Published on: Sat, 26 Apr 2025 06:00:00 -0400
Authors: Nikoleta Parahuleva, Anna Mihaylova, Stanislava Harizanova, Yana Merdzhanova, Mariya Koleva, Vasil Madzharov, Gergana Strikova, Ekaterina Uchikova,
Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women of reproductive age. PCOS is associated with many chronic complications such as endometrial thickening, endometrial cancer, breast cancer, infertility, dyslipidemia, and long-term cardiovascular disease. Therefore, many parameters and markers should be used in the evaluation of patients diagnosed with PCOS. Calprotectin has also been shown to be an important marker of destruction in many diseases that...
Published on: Fri, 25 Apr 2025 06:00:00 -0400
Authors: Rıfat Şener, Süleyman Erkan Alataş, Ömer Tolga Güler,
CONCLUSION: PCOS is associated with an increased risk of persistent hypertension in patients with a history of PHD. Preventive interventions before pregnancy, specific pregnancy surveillance, and long-term follow-up should be recommended for women with PCOS.
Published on: Fri, 25 Apr 2025 06:00:00 -0400
Authors: Stefano Palomba, Flavia Costanzi, Rossella Cannarella, Raffaella Votino, Aldo E Calogero, Fabrizio Signore, Donatella Caserta,
Non-typhoidal Salmonella (NTS), particularly antimicrobial-resistant serovars, remains the major source of foodborne bacterial illnesses. Raw chicken is the leading cause of human salmonellosis. In this study, we evaluated the prevalence, antimicrobial resistance profiles, and genomic features of 143/1,800 (7.94%) Salmonella strains isolated from poultry farms in five major regions of Jiangxi province, China, between 2022 and 2023 using Whole genome sequencing (WGS). Among Salmonella isolates,...
Published on: Fri, 25 Apr 2025 06:00:00 -0400
Authors: Xiaowu Jiang, Abubakar Siddique, Lexin Zhu, Lin Teng, Sajid Umar, Yan Li, Min Yue,
To investigate influences of Dingkun Pill on granulosa cell proliferation and apoptosis (P&A) in polycystic ovary syndrome (PCOS) mice and its association with the TGF-β1/Smad2 signaling pathway (SPW) activity. Forty-eight female SD mice were rolled into experimental group (EG, Dingkun Pill), control group (CG, metformin), model group (MG, distilled water), and normal group (NG, distilled water), with 12 mice per group. The Beloosesky method was employed to establish the PCOS mouse model. Serum...
Published on: Fri, 25 Apr 2025 06:00:00 -0400
Authors: Lan Chen, Xiaojing Yan, Yuanpei Lian, Dijun Wang, Jiali Cai, Chunyan Yin, Ji Cao,
In the modern world, Polycystic Ovary Syndrome (PCOS) is thought to be the most prevalent endocrine condition affecting women. Compared to their normal counterparts, PCOS patients have higher rates of morbidity and death because they are more susceptible to these anomalies from an early age. Cardiovascular disease (CVD) and PCOS are prevalent in women. PCOS often results from a combination of hereditary and environmental causes. Insulin resistance (IR) is considered the primary cause of several...
Published on: Fri, 25 Apr 2025 06:00:00 -0400
Authors: Amandeep Kaur, Ranjeet Kumar, Hardik Kumar, Sonakshi Garg, Abhishek Vijukumar, Dharmendra Kumar,
Polycystic ovary syndrome (PCOS) constitutes a prevalent endocrine disorder among females, exhibiting a significant incidence rate. The etiology of PCOS predominantly attributes to environmental determinants. Phthalate esters, including dibutyl phthalate (DBP) and di(2-ethylhexyl) phthalate (DEHP), have been demonstrated to exert detrimental effects on reproductive function. However, the effects of these plasticizers on female reproductive health have not been clearly investigated. In the...
Published on: Thu, 24 Apr 2025 06:00:00 -0400
Authors: Kang Yi-Fan, Liu Jian-Rong,
Cancer organoids have improved our understanding of recapitulating the histology, genotypes, and drug response of patient tumors for personalized medicine. However, the existing cancer organoids are typically grown in animal-derived matrices (e.g., Matrigel), which suffer from poor reproducibility and low throughput due to uncontrollable origin of seed cells, undefined matrix, and manual manipulation. Here, we report a new strategy to massively generate uniform pancreatic cancer organoids (PCOs)...
Published on: Thu, 24 Apr 2025 06:00:00 -0400
Authors: Haitao Liu, Tingting Tao, Zhongqiao Gan, Yingying Xie, Yaqing Wang, Yizhao Yang, Xu Zhang, Xianliang Li, Jianhua Qin,
